Cyclophilins: Less Studied Proteins with Critical Roles in Pathogenesis.
Identifieur interne : 000810 ( Main/Exploration ); précédent : 000809; suivant : 000811Cyclophilins: Less Studied Proteins with Critical Roles in Pathogenesis.
Auteurs : Khushwant Singh [République tchèque] ; Mark Winter [République tchèque] ; Miloslav Zouhar [République tchèque] ; Pavel Ryšánek [République tchèque]Source :
- Phytopathology [ 0031-949X ] ; 2018.
Descripteurs français
- KwdFr :
- Alignement de séquences (MeSH), Champignons (pathogénicité), Cyclophilines (génétique), Cyclophilines (métabolisme), Immunophilines (métabolisme), Interactions hôte-pathogène (MeSH), Maladies des plantes (immunologie), Maladies des plantes (microbiologie), Modèles moléculaires (MeSH), Oomycetes (pathogénicité), Phylogenèse (MeSH), Plantes (immunologie), Plantes (microbiologie), Séquence d'acides aminés (MeSH), Virulence (MeSH).
- MESH :
- génétique : Cyclophilines.
- immunologie : Maladies des plantes, Plantes.
- microbiologie : Maladies des plantes, Plantes.
- métabolisme : Cyclophilines, Immunophilines.
- pathogénicité : Champignons, Oomycetes.
- Alignement de séquences, Interactions hôte-pathogène, Modèles moléculaires, Phylogenèse, Séquence d'acides aminés, Virulence.
English descriptors
- KwdEn :
- Amino Acid Sequence (MeSH), Cyclophilins (genetics), Cyclophilins (metabolism), Fungi (pathogenicity), Host-Pathogen Interactions (MeSH), Immunophilins (metabolism), Models, Molecular (MeSH), Oomycetes (pathogenicity), Phylogeny (MeSH), Plant Diseases (immunology), Plant Diseases (microbiology), Plants (immunology), Plants (microbiology), Sequence Alignment (MeSH), Virulence (MeSH).
- MESH :
- chemical , genetics : Cyclophilins.
- chemical , metabolism : Cyclophilins, Immunophilins.
- immunology : Plant Diseases, Plants.
- microbiology : Plant Diseases, Plants.
- pathogenicity : Fungi, Oomycetes.
- Amino Acid Sequence, Host-Pathogen Interactions, Models, Molecular, Phylogeny, Sequence Alignment, Virulence.
Abstract
Cyclophilins (EC 5.2.1.8) belong to a subgroup of proteins known as immunophilins, which also include FK506-binding proteins and parvulins. Members of the immunophilins have two main characteristic properties: (i) peptidyl-prolyl cis-trans isomerase activity and (ii) the ability to bind immunosuppressant molecules of fungal origin. Cyclophilins are some of the most conserved proteins present in eukaryotes and prokaryotes, and they have been implicated in diverse cellular processes and responses to multiple biotic and abiotic stresses. Cyclophilins have been exploited in humans and plants extensively, but they have only recently received attention in regard to phytopathogens. In Phellinus sulphurascens and species of the genus Leptosphaeria and Phytophthora, high expression of cyclophilins was found to be related to infection. Moreover, recent studies of cyclophilins in certain phytopathogens, such as Magnaporthe oryzae, Botrytis cinerea, Cryphonectria parasitica, and Puccinia triticina, demonstrated their roles as a pathogenicity factors. In addition to pathogenicity, cyclophilins have high affinity for the immunosuppressive drug cyclosporin A, which is a potent antifungal agent. Although cyclophilins are highly conserved in phytopathogens, because they have been less studied, their role remains largely unknown. In this review, we provide detailed information on the cyclophilins in several phytopathogens, including fungi and oomycetes, as well as their role in suppressing plant immunity.
DOI: 10.1094/PHYTO-05-17-0167-RVW
PubMed: 28643580
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
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first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague</wicri:regionArea><wicri:noRegion>Czech University of Life Sciences Prague</wicri:noRegion></affiliation></author><author><name sortKey="Winter, Mark" sort="Winter, Mark" uniqKey="Winter M" first="Mark" last="Winter">Mark Winter</name><affiliation wicri:level="1"><nlm:affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague</wicri:regionArea><wicri:noRegion>Czech University of Life Sciences Prague</wicri:noRegion></affiliation></author><author><name sortKey="Zouhar, Miloslav" sort="Zouhar, Miloslav" uniqKey="Zouhar M" first="Miloslav" last="Zouhar">Miloslav Zouhar</name><affiliation wicri:level="1"><nlm:affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague</wicri:regionArea><wicri:noRegion>Czech University of Life Sciences Prague</wicri:noRegion></affiliation></author><author><name sortKey="Rysanek, Pavel" sort="Rysanek, Pavel" uniqKey="Rysanek P" first="Pavel" last="Ryšánek">Pavel Ryšánek</name><affiliation wicri:level="1"><nlm:affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</nlm:affiliation><country xml:lang="fr">République tchèque</country><wicri:regionArea>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague</wicri:regionArea><wicri:noRegion>Czech University of Life Sciences Prague</wicri:noRegion></affiliation></author></analytic><series><title level="j">Phytopathology</title><idno type="ISSN">0031-949X</idno><imprint><date when="2018" type="published">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence (MeSH)</term><term>Cyclophilins (genetics)</term><term>Cyclophilins (metabolism)</term><term>Fungi (pathogenicity)</term><term>Host-Pathogen Interactions (MeSH)</term><term>Immunophilins (metabolism)</term><term>Models, Molecular (MeSH)</term><term>Oomycetes (pathogenicity)</term><term>Phylogeny (MeSH)</term><term>Plant Diseases (immunology)</term><term>Plant Diseases (microbiology)</term><term>Plants (immunology)</term><term>Plants (microbiology)</term><term>Sequence Alignment (MeSH)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Alignement de séquences (MeSH)</term><term>Champignons (pathogénicité)</term><term>Cyclophilines (génétique)</term><term>Cyclophilines (métabolisme)</term><term>Immunophilines (métabolisme)</term><term>Interactions hôte-pathogène (MeSH)</term><term>Maladies des plantes (immunologie)</term><term>Maladies des plantes (microbiologie)</term><term>Modèles moléculaires (MeSH)</term><term>Oomycetes (pathogénicité)</term><term>Phylogenèse (MeSH)</term><term>Plantes (immunologie)</term><term>Plantes (microbiologie)</term><term>Séquence d'acides aminés (MeSH)</term><term>Virulence (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Cyclophilins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Cyclophilins</term><term>Immunophilins</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Cyclophilines</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Maladies des plantes</term><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Plant Diseases</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Maladies des plantes</term><term>Plantes</term></keywords><keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>Plant Diseases</term><term>Plants</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Cyclophilines</term><term>Immunophilines</term></keywords><keywords scheme="MESH" qualifier="pathogenicity" xml:lang="en"><term>Fungi</term><term>Oomycetes</term></keywords><keywords scheme="MESH" qualifier="pathogénicité" xml:lang="fr"><term>Champignons</term><term>Oomycetes</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>Host-Pathogen Interactions</term><term>Models, Molecular</term><term>Phylogeny</term><term>Sequence Alignment</term><term>Virulence</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Alignement de séquences</term><term>Interactions hôte-pathogène</term><term>Modèles moléculaires</term><term>Phylogenèse</term><term>Séquence d'acides aminés</term><term>Virulence</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Cyclophilins (EC 5.2.1.8) belong to a subgroup of proteins known as immunophilins, which also include FK506-binding proteins and parvulins. Members of the immunophilins have two main characteristic properties: (i) peptidyl-prolyl cis-trans isomerase activity and (ii) the ability to bind immunosuppressant molecules of fungal origin. Cyclophilins are some of the most conserved proteins present in eukaryotes and prokaryotes, and they have been implicated in diverse cellular processes and responses to multiple biotic and abiotic stresses. Cyclophilins have been exploited in humans and plants extensively, but they have only recently received attention in regard to phytopathogens. In Phellinus sulphurascens and species of the genus Leptosphaeria and Phytophthora, high expression of cyclophilins was found to be related to infection. Moreover, recent studies of cyclophilins in certain phytopathogens, such as Magnaporthe oryzae, Botrytis cinerea, Cryphonectria parasitica, and Puccinia triticina, demonstrated their roles as a pathogenicity factors. In addition to pathogenicity, cyclophilins have high affinity for the immunosuppressive drug cyclosporin A, which is a potent antifungal agent. Although cyclophilins are highly conserved in phytopathogens, because they have been less studied, their role remains largely unknown. In this review, we provide detailed information on the cyclophilins in several phytopathogens, including fungi and oomycetes, as well as their role in suppressing plant immunity.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">28643580</PMID><DateCompleted><Year>2018</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2018</Year><Month>04</Month><Day>19</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0031-949X</ISSN><JournalIssue CitedMedium="Print"><Volume>108</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>Jan</Month></PubDate></JournalIssue><Title>Phytopathology</Title><ISOAbbreviation>Phytopathology</ISOAbbreviation></Journal><ArticleTitle>Cyclophilins: Less Studied Proteins with Critical Roles in Pathogenesis.</ArticleTitle><Pagination><MedlinePgn>6-14</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1094/PHYTO-05-17-0167-RVW</ELocationID><Abstract><AbstractText>Cyclophilins (EC 5.2.1.8) belong to a subgroup of proteins known as immunophilins, which also include FK506-binding proteins and parvulins. Members of the immunophilins have two main characteristic properties: (i) peptidyl-prolyl cis-trans isomerase activity and (ii) the ability to bind immunosuppressant molecules of fungal origin. Cyclophilins are some of the most conserved proteins present in eukaryotes and prokaryotes, and they have been implicated in diverse cellular processes and responses to multiple biotic and abiotic stresses. Cyclophilins have been exploited in humans and plants extensively, but they have only recently received attention in regard to phytopathogens. In Phellinus sulphurascens and species of the genus Leptosphaeria and Phytophthora, high expression of cyclophilins was found to be related to infection. Moreover, recent studies of cyclophilins in certain phytopathogens, such as Magnaporthe oryzae, Botrytis cinerea, Cryphonectria parasitica, and Puccinia triticina, demonstrated their roles as a pathogenicity factors. In addition to pathogenicity, cyclophilins have high affinity for the immunosuppressive drug cyclosporin A, which is a potent antifungal agent. Although cyclophilins are highly conserved in phytopathogens, because they have been less studied, their role remains largely unknown. In this review, we provide detailed information on the cyclophilins in several phytopathogens, including fungi and oomycetes, as well as their role in suppressing plant immunity.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Singh</LastName><ForeName>Khushwant</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winter</LastName><ForeName>Mark</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zouhar</LastName><ForeName>Miloslav</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ryšánek</LastName><ForeName>Pavel</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>First author: Division of Crop Protection and Plant Health, Crop Research Institute, Drnovská 507, 16106 Prague, Czech Republic; first and second authors: Plant Pathology and Crop Protection Division, Department of Crop Sciences, Faculty of Agriculture, Georg-August-University Göttingen, Germany; and first, third, and fourth authors: Department of Plant Protection, Faculty of Agrobiology, Food and Natural Resources, Czech University of Life Sciences Prague, Czech Republic.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2017</Year><Month>09</Month><Day>29</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Phytopathology</MedlineTA><NlmUniqueID>9427222</NlmUniqueID><ISSNLinking>0031-949X</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>EC 5.2.1.-</RegistryNumber><NameOfSubstance UI="D021983">Cyclophilins</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 5.2.1.8</RegistryNumber><NameOfSubstance UI="D020104">Immunophilins</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000595" MajorTopicYN="N">Amino Acid Sequence</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D021983" MajorTopicYN="N">Cyclophilins</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005658" MajorTopicYN="N">Fungi</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D054884" MajorTopicYN="N">Host-Pathogen Interactions</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020104" MajorTopicYN="N">Immunophilins</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008958" MajorTopicYN="N">Models, Molecular</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D009868" MajorTopicYN="N">Oomycetes</DescriptorName><QualifierName UI="Q000472" MajorTopicYN="Y">pathogenicity</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010802" MajorTopicYN="N">Phylogeny</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010935" MajorTopicYN="N">Plant Diseases</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010944" MajorTopicYN="N">Plants</DescriptorName><QualifierName UI="Q000276" MajorTopicYN="Y">immunology</QualifierName><QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016415" MajorTopicYN="N">Sequence Alignment</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D014774" MajorTopicYN="N">Virulence</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">protists</Keyword><Keyword MajorTopicYN="Y">virulence</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2017</Year><Month>6</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2018</Year><Month>4</Month><Day>20</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2017</Year><Month>6</Month><Day>24</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">28643580</ArticleId><ArticleId IdType="doi">10.1094/PHYTO-05-17-0167-RVW</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>République tchèque</li></country></list><tree><country name="République tchèque"><noRegion><name sortKey="Singh, Khushwant" sort="Singh, Khushwant" uniqKey="Singh K" first="Khushwant" last="Singh">Khushwant Singh</name></noRegion><name sortKey="Rysanek, Pavel" sort="Rysanek, Pavel" uniqKey="Rysanek P" first="Pavel" last="Ryšánek">Pavel Ryšánek</name><name sortKey="Winter, Mark" sort="Winter, Mark" uniqKey="Winter M" first="Mark" last="Winter">Mark Winter</name><name sortKey="Zouhar, Miloslav" sort="Zouhar, Miloslav" uniqKey="Zouhar M" first="Miloslav" last="Zouhar">Miloslav Zouhar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a PhytophthoraV1
| This area was generated with Dilib version V0.6.38. |  |